index

index

MEDLINE 字段标识

这些两个字母的字段标识可标识您通过电子邮件发送或保存到文件的记录中的字段。

FN

文件名

VR

版本号

PT

出版物类型

AN

PubMed ID

DT

文献类型 (J = 期刊)

TI

标题

FT

原语种标题

AU

作者

CA

机构作者

SO

来源出版物(卷、期、页码、出版年)

VL

IS

PS

PY

出版年

PD

公开日期

LA

语种

AB

摘要

A2

其他摘要

C1

作者地址

RI

Web of Science ResearcherID 号

OI

ORCID 标识符 (Open Researcher and Contributor ID)

MH

MeSH 词表

SS

分主题子库

ID

关键字列表

SD

分子序列

GN

基因符号

CN

化学

NM

个人名称主题

SF

Space Flight Mission

SC

研究方向

SN

国际标准期刊号 (ISSN)

U1

使用次数(最近 180 天)

U2

使用次数(2013 年至今)

JC

NLM 唯一 ID

PA

国家/地区

GI

许可信息

OB

记录所有者

SA

状态

IV

调查人

NR

引用的参考文献数

RC

创建日期、完成日期、修订日期

NO

备注、校正、勘误

PE

电子出版物

NT

一般注释

DI

数字对象标识符 (DOI)

UT

ISI 论文唯一标识符

OA

公开访问指示符

HP

ESI 热门论文。请注意,此字段值仅适用于 ESI 订阅者

HC

ESI 高被引论文请注意,此字段值仅适用于 ESI 订阅者

DA

生成此报告的日期

ER

[记录结束]

EF

[文件结束]

index

输出记录示例 - 保存为 HTML 格式

FN

Clarivate

VR

1.0

PT

J

AN

22189395

DT

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

TI

The molecular classification of medulloblastoma: driving the next generation clinical trials.

AU

Leary, Sarah E S
Olson, James M

SO

Current opinion in pediatrics

VL

24

IS

1

PS

33-9

PY

2012

PD

2012 Feb

LA

英文

AB

PURPOSE OF REVIEW: Most children diagnosed with cancer today are expected to be cured.Medulloblastoma, the most common pediatric malignant brain tumor, is an example of a disease that has benefitted from advances in diagnostic imaging, surgical techniques, radiation therapy and combination chemotherapy over the past decades.It was an incurable disease 50 years ago, but approximately 70% of children with medulloblastoma are now cured of their disease.However, the pace of increasing the cure rate has slowed over the past 2 decades, and we have likely reached the maximal benefit that can be achieved with cytotoxic therapy and clinical risk stratification.Long-term toxicity of therapy also remains significant.To increase cure rates and decrease long-term toxicity, there is great interest in incorporating biologic 'targeted' therapy into treatment of medulloblastoma, but this will require a paradigm shift in how we classify and study disease.RECENT FINDINGS: Using genome-based high-throughput analytic techniques, several groups have independently reported methods of molecular classification of medulloblastoma within the past year.This has resulted in a working consensus to view medulloblastoma as four molecular subtypes, including wingless-type murine mammary tumor virus integration site (WNT) pathway subtype, Sonic Hedgehog pathway subtype and two less well defined subtypes (groups C and D).SUMMARY: Novel classification and risk stratification based on biologic subtypes of disease will form the basis of further study in medulloblastoma and identify specific subtypes that warrant greater research focus.

C1

Seattle Children's Hospital, University of Washington School of Medicine, Washington, USA. sarah.leary@seattlechildrens.org

SS

Index Medicus

SN

1531-698X

JC

9000850

PA

United States

GI

R01CA112350 / NCI NIH HHS.R01CA114567 / NCI NIH HHS

SA

In-Process

RC

16 Jan 2012

UT

MEDLINE:22189395

ER

EF

index

默认输出字段

以下字段是在“标记结果列表”页面上的默认输出字段。

  • 作者
  • 标题
  • 来源出版物
  • ISSN 
  • 作者标识符

您可以在生成输出时取消选中这些字段。

index

有关信息……