MEDLINE 字段标识
这些两个字母的字段标识可标识您通过电子邮件发送或保存到文件的记录中的字段。
FN |
文件名
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VR |
版本号
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PT |
出版物类型
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AN |
PubMed ID
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DT |
文献类型 (J = 期刊)
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TI |
标题
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FT |
原语种标题
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AU |
作者
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CA |
机构作者
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SO |
来源出版物(卷、期、页码、出版年)
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VL |
卷
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IS |
期
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PS |
页
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PY |
出版年
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PD |
公开日期
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LA |
语种
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AB |
摘要
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A2 |
其他摘要
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C1 |
作者地址
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RI |
Web of Science ResearcherID 号
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OI |
ORCID 标识符 (Open Researcher and Contributor ID)
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MH |
MeSH 词表
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SS |
分主题子库
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ID |
关键字列表
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SD |
分子序列
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GN |
基因符号
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CN |
化学
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NM |
个人名称主题
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SF |
Space Flight Mission
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SC |
研究方向
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SN |
国际标准期刊号 (ISSN)
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U1 |
使用次数(最近 180 天)
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U2 |
使用次数(2013 年至今)
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JC |
NLM 唯一 ID
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PA |
国家/地区
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GI |
许可信息
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OB |
记录所有者
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SA |
状态
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IV |
调查人
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NR |
引用的参考文献数
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RC |
创建日期、完成日期、修订日期
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NO |
备注、校正、勘误
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PE |
电子出版物
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NT |
一般注释
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DI |
数字对象标识符 (DOI)
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UT |
ISI 论文唯一标识符
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OA |
公开访问指示符
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HP |
ESI 热门论文。请注意,此字段值仅适用于 ESI 订阅者
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HC |
ESI 高被引论文请注意,此字段值仅适用于 ESI 订阅者
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DA |
生成此报告的日期
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ER |
[记录结束]
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EF |
[文件结束]
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输出记录示例 - 保存为 HTML 格式
PT
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J
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AN
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22189395
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DT
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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TI
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The molecular classification of medulloblastoma: driving the next generation clinical trials.
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AU
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Leary, Sarah E S Olson, James M
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SO
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Current opinion in pediatrics
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VL
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24
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IS
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1
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PS
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33-9
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PY
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2012
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PD
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2012 Feb
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LA
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英文
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AB
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PURPOSE OF REVIEW: Most children diagnosed with cancer today are expected to be cured.Medulloblastoma, the most common pediatric malignant brain tumor, is an example of a disease that has benefitted from advances in diagnostic imaging, surgical techniques, radiation therapy and combination chemotherapy over the past decades.It was an incurable disease 50 years ago, but approximately 70% of children with medulloblastoma are now cured of their disease.However, the pace of increasing the cure rate has slowed over the past 2 decades, and we have likely reached the maximal benefit that can be achieved with cytotoxic therapy and clinical risk stratification.Long-term toxicity of therapy also remains significant.To increase cure rates and decrease long-term toxicity, there is great interest in incorporating biologic 'targeted' therapy into treatment of medulloblastoma, but this will require a paradigm shift in how we classify and study disease.RECENT FINDINGS: Using genome-based high-throughput analytic techniques, several groups have independently reported methods of molecular classification of medulloblastoma within the past year.This has resulted in a working consensus to view medulloblastoma as four molecular subtypes, including wingless-type murine mammary tumor virus integration site (WNT) pathway subtype, Sonic Hedgehog pathway subtype and two less well defined subtypes (groups C and D).SUMMARY: Novel classification and risk stratification based on biologic subtypes of disease will form the basis of further study in medulloblastoma and identify specific subtypes that warrant greater research focus.
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C1
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Seattle Children's Hospital, University of Washington School of Medicine, Washington, USA. sarah.leary@seattlechildrens.org
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SS
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Index Medicus
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SN
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1531-698X
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JC
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9000850
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PA
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United States
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GI
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R01CA112350 / NCI NIH HHS.R01CA114567 / NCI NIH HHS
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SA
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In-Process
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RC
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16 Jan 2012
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UT
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MEDLINE:22189395
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ER
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